Studies in Carbohydrate Metabolism. Ix. Tee Influence of Hydrazine on the Glyoxalase Activity of the Liver

Modern theories of metabolism assign vast importance to enzyme action. These hypotheses, though completely in accord with the facts as determined in vitro, should be extended to processes in the body with great caution. In accordance with our present ideas, howeve, it seems quite possible that the peculiar effect that hydraaine2 produces on the sugar content of the blood may be due to some interference with the essential enzymatic activities. In this connection three possibilities suggest themselves. The enzyme or enzymes concerned may be accelerated, retarded, or entirely destroyed.